Parental GM and HLA genotypes and reduced birth weight in patients with Turner's syndrome.
Identifieur interne : 012A93 ( Main/Exploration ); précédent : 012A92; suivant : 012A94Parental GM and HLA genotypes and reduced birth weight in patients with Turner's syndrome.
Auteurs : Daniela Larizza [Italie] ; Miryam Martinetti ; Jean Michel Dugoujon ; Carmine Tinelli ; Valeria Calcaterra ; Mariaclara Cuccia ; Laura Salvaneschi ; Francesca SeveriSource :
- Journal of pediatric endocrinology & metabolism : JPEM [ 0334-018X ]
Descripteurs français
- KwdFr :
- 17alpha-Hydroxyprogestérone (sang), Antigènes HLA (génétique), Cardiopathies congénitales (génétique), Chaines gamma des immunoglobulines (génétique), Chaines légères kappa des immunoglobulines (génétique), Femelle, Hormone corticotrope, Humains, Italie, Mâle, Nouveau-né, Parents, Poids de naissance (génétique), Rang de naissance, Rein (malformations), Syndrome de Turner (génétique), Âge gestationnel.
- MESH :
- génétique : Antigènes HLA, Cardiopathies congénitales, Chaines gamma des immunoglobulines, Chaines légères kappa des immunoglobulines, Poids de naissance, Syndrome de Turner.
- malformations : Rein.
- sang : 17alpha-Hydroxyprogestérone.
- Femelle, Hormone corticotrope, Humains, Italie, Mâle, Nouveau-né, Parents, Rang de naissance, Âge gestationnel.
- Wicri :
- geographic : Italie.
English descriptors
- KwdEn :
- 17-alpha-Hydroxyprogesterone (blood), Adrenocorticotropic Hormone, Birth Order, Birth Weight (genetics), Female, Gestational Age, HLA Antigens (genetics), Heart Defects, Congenital (genetics), Humans, Immunoglobulin gamma-Chains (genetics), Immunoglobulin kappa-Chains (genetics), Infant, Newborn, Italy, Kidney (abnormalities), Male, Parents, Turner Syndrome (genetics).
- MESH :
- chemical , blood : 17-alpha-Hydroxyprogesterone.
- chemical , genetics : HLA Antigens, Immunoglobulin gamma-Chains, Immunoglobulin kappa-Chains.
- chemical : Adrenocorticotropic Hormone.
- geographic : Italy.
- abnormalities : Kidney.
- genetics : Birth Weight, Heart Defects, Congenital, Turner Syndrome.
- Birth Order, Female, Gestational Age, Humans, Infant, Newborn, Male, Parents.
Abstract
We investigated a possible influence on birth weight in Turner's syndrome of many clinical, hormonal, genetic and immunogenetic variables. We considered 97 patients with Turner's syndrome. Patients with parents with identical GM (Gamma heavy chains Marker) phenotype had a significantly lower birth weight than those with parents with different GM phenotype. Karyotype other than 45,X, HLA (Human Leukocyte Antigen) parental sharing, mother-patient compatibility and elevated 17-hydroxyprogesterone (17OHP) serum level after adrenocorticotropin hormone (ACTH) and absence of heart and kidney malformations and lymphedema were associated with a lower birth weight, but not significantly. Multiple interactions showed that the presence of an identical GM phenotype in parents, together with other conditions (karyotype other than 45,X, adrenal dysfunction, HLA parental sharing, mother-child compatibility, KM(3) [Kappa light chains Marker] phenotype) resulted in a further decrease of birth weight. These data might suggest a negative effect of genetic similarity on intrauterine growth in Turner's syndrome.
PubMed: 12387517
Affiliations:
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Le document en format XML
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Carmine" sort="Tinelli, Carmine" uniqKey="Tinelli C" first="Carmine" last="Tinelli">Carmine Tinelli</name></author><author><name sortKey="Calcaterra, Valeria" sort="Calcaterra, Valeria" uniqKey="Calcaterra V" first="Valeria" last="Calcaterra">Valeria Calcaterra</name></author><author><name sortKey="Cuccia, Mariaclara" sort="Cuccia, Mariaclara" uniqKey="Cuccia M" first="Mariaclara" last="Cuccia">Mariaclara Cuccia</name></author><author><name sortKey="Salvaneschi, Laura" sort="Salvaneschi, Laura" uniqKey="Salvaneschi L" first="Laura" last="Salvaneschi">Laura Salvaneschi</name></author><author><name sortKey="Severi, Francesca" sort="Severi, Francesca" uniqKey="Severi F" first="Francesca" last="Severi">Francesca Severi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2002 Sep-Oct</MedlineDate></PubDate></date><idno type="RBID">pubmed:12387517</idno><idno type="pmid">12387517</idno><idno 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sortKey="Larizza, Daniela" sort="Larizza, Daniela" uniqKey="Larizza D" first="Daniela" last="Larizza">Daniela Larizza</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, University of Pavia, Italy. d.larizza@smatteo.pv.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pediatrics, University of Pavia</wicri:regionArea><wicri:noRegion>University of Pavia</wicri:noRegion></affiliation></author><author><name sortKey="Martinetti, Miryam" sort="Martinetti, Miryam" uniqKey="Martinetti M" first="Miryam" last="Martinetti">Miryam Martinetti</name></author><author><name sortKey="Dugoujon, Jean Michel" sort="Dugoujon, Jean Michel" uniqKey="Dugoujon J" first="Jean Michel" last="Dugoujon">Jean Michel Dugoujon</name></author><author><name sortKey="Tinelli, Carmine" sort="Tinelli, Carmine" uniqKey="Tinelli C" first="Carmine" last="Tinelli">Carmine Tinelli</name></author><author><name sortKey="Calcaterra, Valeria" sort="Calcaterra, Valeria" uniqKey="Calcaterra V" first="Valeria" last="Calcaterra">Valeria Calcaterra</name></author><author><name sortKey="Cuccia, Mariaclara" sort="Cuccia, Mariaclara" uniqKey="Cuccia M" first="Mariaclara" last="Cuccia">Mariaclara Cuccia</name></author><author><name sortKey="Salvaneschi, Laura" sort="Salvaneschi, Laura" uniqKey="Salvaneschi L" first="Laura" last="Salvaneschi">Laura Salvaneschi</name></author><author><name sortKey="Severi, Francesca" sort="Severi, Francesca" uniqKey="Severi F" first="Francesca" last="Severi">Francesca Severi</name></author></analytic><series><title level="j">Journal of pediatric endocrinology & metabolism : JPEM</title><idno type="ISSN">0334-018X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>17-alpha-Hydroxyprogesterone (blood)</term><term>Adrenocorticotropic Hormone</term><term>Birth Order</term><term>Birth Weight (genetics)</term><term>Female</term><term>Gestational Age</term><term>HLA Antigens (genetics)</term><term>Heart Defects, Congenital (genetics)</term><term>Humans</term><term>Immunoglobulin gamma-Chains (genetics)</term><term>Immunoglobulin kappa-Chains (genetics)</term><term>Infant, Newborn</term><term>Italy</term><term>Kidney (abnormalities)</term><term>Male</term><term>Parents</term><term>Turner Syndrome (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>17alpha-Hydroxyprogestérone (sang)</term><term>Antigènes HLA (génétique)</term><term>Cardiopathies congénitales (génétique)</term><term>Chaines gamma des immunoglobulines (génétique)</term><term>Chaines légères kappa des immunoglobulines (génétique)</term><term>Femelle</term><term>Hormone corticotrope</term><term>Humains</term><term>Italie</term><term>Mâle</term><term>Nouveau-né</term><term>Parents</term><term>Poids de naissance (génétique)</term><term>Rang de naissance</term><term>Rein (malformations)</term><term>Syndrome de Turner (génétique)</term><term>Âge gestationnel</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>17-alpha-Hydroxyprogesterone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA Antigens</term><term>Immunoglobulin gamma-Chains</term><term>Immunoglobulin kappa-Chains</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adrenocorticotropic Hormone</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Italy</term></keywords><keywords scheme="MESH" qualifier="abnormalities" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Birth Weight</term><term>Heart Defects, Congenital</term><term>Turner Syndrome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA</term><term>Cardiopathies congénitales</term><term>Chaines gamma des immunoglobulines</term><term>Chaines légères kappa des immunoglobulines</term><term>Poids de naissance</term><term>Syndrome de Turner</term></keywords><keywords scheme="MESH" qualifier="malformations" xml:lang="fr"><term>Rein</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>17alpha-Hydroxyprogestérone</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Birth Order</term><term>Female</term><term>Gestational Age</term><term>Humans</term><term>Infant, Newborn</term><term>Male</term><term>Parents</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Hormone corticotrope</term><term>Humains</term><term>Italie</term><term>Mâle</term><term>Nouveau-né</term><term>Parents</term><term>Rang de naissance</term><term>Âge gestationnel</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Italie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated a possible influence on birth weight in Turner's syndrome of many clinical, hormonal, genetic and immunogenetic variables. We considered 97 patients with Turner's syndrome. Patients with parents with identical GM (Gamma heavy chains Marker) phenotype had a significantly lower birth weight than those with parents with different GM phenotype. Karyotype other than 45,X, HLA (Human Leukocyte Antigen) parental sharing, mother-patient compatibility and elevated 17-hydroxyprogesterone (17OHP) serum level after adrenocorticotropin hormone (ACTH) and absence of heart and kidney malformations and lymphedema were associated with a lower birth weight, but not significantly. Multiple interactions showed that the presence of an identical GM phenotype in parents, together with other conditions (karyotype other than 45,X, adrenal dysfunction, HLA parental sharing, mother-child compatibility, KM(3) [Kappa light chains Marker] phenotype) resulted in a further decrease of birth weight. These data might suggest a negative effect of genetic similarity on intrauterine growth in Turner's syndrome.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Calcaterra, Valeria" sort="Calcaterra, Valeria" uniqKey="Calcaterra V" first="Valeria" last="Calcaterra">Valeria Calcaterra</name><name sortKey="Cuccia, Mariaclara" sort="Cuccia, Mariaclara" uniqKey="Cuccia M" first="Mariaclara" last="Cuccia">Mariaclara Cuccia</name><name sortKey="Dugoujon, Jean Michel" sort="Dugoujon, Jean Michel" uniqKey="Dugoujon J" first="Jean Michel" last="Dugoujon">Jean Michel Dugoujon</name><name sortKey="Martinetti, Miryam" sort="Martinetti, Miryam" uniqKey="Martinetti M" first="Miryam" last="Martinetti">Miryam Martinetti</name><name sortKey="Salvaneschi, Laura" sort="Salvaneschi, Laura" uniqKey="Salvaneschi L" first="Laura" last="Salvaneschi">Laura Salvaneschi</name><name sortKey="Severi, Francesca" sort="Severi, Francesca" uniqKey="Severi F" first="Francesca" last="Severi">Francesca Severi</name><name sortKey="Tinelli, Carmine" sort="Tinelli, Carmine" uniqKey="Tinelli C" first="Carmine" last="Tinelli">Carmine Tinelli</name></noCountry><country name="Italie"><noRegion><name sortKey="Larizza, Daniela" sort="Larizza, Daniela" uniqKey="Larizza D" first="Daniela" last="Larizza">Daniela Larizza</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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